By attending the course, students learn the following skills. They are able to:
- understand and explain basic functions of the neren system and muscle cells (k1/k2),
- formulate and interpret simple structure/function relationships of protein (k3),
- Describe a complete signaling pathway step by step (ligand → → second messenger → cell response) k1/k2
- predict which cell response fails when individual components are activated or blocked k2/k3
- explain why the same ligand triggers different effects in different cell types k1/k2
- Clearly distinguish RTK signaling pathways from GPCR signaling pathways and mechanistically justify pathological activations (e.g., oncogenes) k1/k2
- Explain how a GPCR affects Ca²⁺ signaling, membrane potential, or gene expression k1/k2
- Changes in heart rate or contractility molecularly justify k1/k2
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Macroscopic structure of the nervous system, nerve cell structures, ion transport, action potential, structure and molecular structure of synapses and ion channels, as well as their function on the basis of biophysical analysis. techniques such as Ca2+ imaging, patch clamp and crystallography; Synapse, Molecular Mechanisms of Excitation Secretion-Coupling, Neural Plasticity and Long Term Potentiation, Pathophysiolgia and Treatment of Parkinsonism and Epilepsy. Muscular endplate and excitation-contraction-coupling, peripheral, autonomic nervous system, peripheral receptors and neurotransmitters, basic features of molecular pharmacology, the path from extracellular ligand to spec. Gene expression or Ca++ release in a cell, receptor tyrosine kinases, G-protein-coupled receptors, overview of the structure of the heart, action potentials in the heart, molecular effect of acetylcholine and norepinephrine on the heart and blood vessels, overview and mode of action of second messenger systems (cAMP, cGMP, IP3, DAG, NO, Ca2+), kinases, phospholipases,
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