| After this course, students know the essentials of the NMR spectroscopy technique. Students know the relationship between magnetic field, NMR sensitivity, isotopes, nuclear shielding and the chemical shift (k1,k2). Students can predict the spin-spin coupling fine structure from a given structure, and vice versa (k3). Students know how simple pulse FT NMR experiments work and how data is recorded and displayed (k1,k3). Students can apply the Pople rules to provide spin system nomenclature (k3). Students can reflect on how internal and chemical dynamics affect NMR spectra (k2,k3). Students can rationalize the way decoupling affects NMR spectra (k4). Students can describe elementary relaxation processes (k1). The students understand how basic homonuclear and heteronuclear 2D NMR methods work and what information is contained in the spectra (k1). Students can differentiate between correct and incorrect structure/spectra combinations and suggest molecular fragments based on spectral appearance (k3,k4).
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• Double bond equivalent
• Mathematical equations that describe basic spin physics of NMR
• Equations that describe T1 and T2 relaxation
• The layout of an NMR spectrometer
• Concepts of chemical and magnetic (in)equivalence
• Spin coupling rules and the naming of multiplets.
• 1H and 13C NMR
• Chemical shift scales for organic molecules and origins of (de)shielding
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