Menü
Positionsanzeige
Inhalt

[ 863STBTSTB24 ] Modul (*)Structural Biochemistry
Versionsauswahl
(*) Leider ist diese Information in Deutsch nicht verfügbar.
Workload Form der Prüfung Ausbildungslevel Studienfachbereich VerantwortlicheR Anbietende Uni
4 ECTS Kumulative Modulprüfung M1 - Master 1. Jahr Biologische Chemie Jan Sterba USB Budweis
Detailinformationen
Quellcurriculum Masterstudium Biological Chemistry 2024W
Ziele (*)The lectures will give students an insight into why it is important to understand the function of macromolecular structures at the molecular level. There have been breakthroughs in modern biochemistry with the development of techniques such as XRD, NMR and EM that allow the structures of macromolecules to be determined. Today, students commonly use structural models of proteins and nucleic acids available in computer databases. These models provide an illustrative but often idealised representation of biological macromolecules. It is therefore crucial that students of modern biochemistry become familiar with structural analysis methods during their studies. By doing so, they will be able to distinguish between what has been measured and what has been calculated and thus better understand the difference between reality and the model.
Lehrinhalte (*)Content of Lectures: Chemical structure and geometry, conformation and energy (Michal Kutý) Structure of proteins (Ivana Kutá Smatanová, Michal Kutý) Structure of nucleic acids (Tomáš Fessl) Structure of polysaccharides and biological membranes (František Vácha) Computational methods and molecular modelling (Michal Kutý) X-ray crystallography (Pavlína Řezáčová) Nuclear Magnetic Resonance (Vašek Veverka) Electron microscopy (Zdenko Gardian) Mass spectroscopy (Filip Dyčka, Peter Koník) Absorption and fluorescence spectroscopy (Radek Litvín) Optical microscopy and CD (Tomáš Fessl) New trends in structural biochemistry (Ivana Kutá Smatanová)
Sonstige Informationen (*)Content of Practicals: (Barbora Kaščáková, Petra Havlíčková) The knowledge acquired during the lectures will be deepened during the exercise. Solving the structure of a selected protein, visualization using Pymol, using a program for structure prediction (AlphaFold)

Criteria for evaluation The final exam will take the form of oral interview with the final evaluation in the form of awarding the mark

Methods Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Individual tutoring

Study Material Kensal E. van Holde, W. Curtis Johnson, P. Shing Ho: Principles of physical biochemistry 2nd ed. Pearson Education, Inc. (2006), ISBN 0-13-046427-9

Language English

Untergeordnete Studienfächer, Module und Lehrveranstaltungen