[ 491ANCHMSPV19 ] VL Mass Spectrometry

Workload Education level Study areas Responsible person Hours per week Coordinating university
1,5 ECTS M2 - Master's programme 2. year Chemistry Markus Himmelsbach 1 hpw Johannes Kepler University Linz
Detailed information
Original study plan Master's programme Chemistry and Chemical Technology (CCT) 2019W
Objectives The course provides in depth information on modern, state-of-the-art instrumentation in mass spectrometry. These include various ionization methods for liquids, solids and gaseous samples, as well as high resolution mass analyzers and ion mobility mass spectrometry.
Subject The lecture starts with „Fundamentals“, where mass spectrometry relevant general information and terms are discussed briefly. The major lecture topics are:

1. Ion Sources. Commercially available ion source like Electron Ionization, Chemical Ionization, Electrospray Ionization, Atmospheric Pressure Chemical Ionization, Atmospheric Pressure Photoionization, Desorption Electrospray Ionization, Direct Analysis in Real Time, Matrix-Assisted Laser Desorption Ionization and Inorganic Mass Spectrometry Ion Sources are presented.

2. Mass Analyzers. This chapter includes Quadrupole Instruments, Ion-Traps (3D/2D), TOF, Sector Instruments, FT-ICR and Orbitrap. The working principles are explained with the focus on useful practical decision-making what instrument can be used for particular tasks.

3. Tandem Mass Spectrometry. The most important tandem MS strategies are given, highlighting possible mass analyzer combinations which are best suited for certain fields of application.

4. Ion Mobility Spectrometry - Mass Spectrometry is a very recent field with fast growing applications and technical improvements. Established methods like DTIMS, TWIMS, FAIMS/DMS are presented together with latest developments, e.g. TIMS.

Criteria for evaluation Oral exam
Methods PowerPoint presentation. Lecture slides will be provided online.
Language English
Study material Lecture slides will be provided online.

Optional literature:

[1] Jürgen H. Gross: Mass Spectrometry - A Textbook, Second Edition, Springer, New York, 2011

[2] Rolf Ekman, Jerzy Silberring, Ann Westman-Brinkmalm, Agnieszka Kraj: Mass Spectrometry. Instrumentation, Interpretation, and Applications, John Wiley & Sons, Inc., Hoboken, New Jersey, 2009

[3] Edmond de Hoffmann, Vincent Stroobant: Mass Spectrometry. Principles and Applications, Third Edition, John Wiley & Sons Ltd, West Sussex, England, 2007

Changing subject? No
Corresponding lecture 491WACHSE1V10: VL Spectroscopy and Structure Elucidation II (1.3 ECTS)
On-site course
Maximum number of participants -
Assignment procedure Direct assignment