Studienhandbuch | VL Physical Chemistry for Biological Chemistry I

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[ 663PHCHPC1V20 ] VL Physical Chemistry for Biological Chemistry I

Versionsauswahl

Workload	Education level	Study areas	Responsible person	Hours per week	Coordinating university
4,5 ECTS	B3 - Bachelor's programme 3. year	^(*)Biologische Chemie	Sabine Hild	3 hpw	Johannes Kepler University Linz

Detailed information
Original study plan	Bachelor's programme Biological Chemistry 2018W
Objectives	The lecture conveys to the students the principles of physical chemistry and their application to the study of life sciences, particularly biology and biochemistry.
Subject	Introduction A. The structure of Physical Chemistry B. Application of Physical Chemistry to Biology Fundamentals F1. Atoms, ions, and Molecules F2. Bulk Matter F3. Energy Part 1: Biological Thermodynamics 1. The First Law The Conservation of Energy 1.1. Systems and Surroundings 1.2. Work and Heat 1.3. The measurement of work 1.4. The measurement of heat Internal energy and enthalpy 1.5. The Internal Energy 1.6. The Enthalpy 1.7. Enthalpy changes accompanying physical processes 1.8. Bond Enthalpy 1.9. Thermochemical properties of fuels 1.10. The combination of reaction enthalpies 1.11. Standard Enthalpy of formation 1.12. The Enthalpy of formation and computational chemistry 1.13. The variation of reaction enthalpy with temperature 2. The Second Law Entropy 2.1. The direction of spontaneous changes 2.2. Entropy and the Second Law 2.3. Absolute entropies and the Third Law of Thermodynamics 2.4. The molecular interpretation of the Second Law and Third Laws 2.5. Entropy Changes accompanying chemical reactions The Gibbs energy 2.6. Focusing on the System 2.7. The Hydrophobic interaction 2.8. Work and the Gibbs energy change 3. Phase (Physical) equilibra The thermodynamics of transition 3.1. The condition of stability 3.2. The variation of Gibbs energy with pressure 3.3. The variation of Gibbs energy with temperature 3.4. Phase diagrams Phase transitions in biopolymers and aggregates 3.5. The stability of nucleic acids and proteins 3.6. Phase transitions in biological membranes The thermodynamic description of mixtures 3.7. The chemical potential 3.8. Ideal and ideal-dilute solutions Colligative properties 3.9. The modification of boiling and freezing points 3.10. Osmosis 4. Chemical equilibria Thermodynamic background 4.1. The reaction Gibbs Energy 4.2. The variation G with composition 4.3. Reactions at equilibrium 4.4. The standard reaction Gibbs energy 4.5. The presence of a catalyst 4.6. The effect of temperature Proton transfer equilibria 4.7. Bronsted-Lowry theory 4.8. Protonation and deprotonation 4.9. Polyprotic acids 4.10. Amphiprotic systems 4.11. Buffer solutions 5. Thermodynamics of ions and electron transport Transport of ions across biological membranes 5.1. Ions in solution 5.2. Passive and active transport of ions across biological membranes 5.3. Ion channels and ion pumps Redox reactions 5.4. Half-reactions 5.5. Reactions in electrochemical cells 5.6. The Nernst equation 5.7. The standard potential Applications of standard potentials 5.8. The determinationof thermodynamic functions 5.9. The electrochemical series Electron transfer in bioenergetics 5.10. The respiratory chain 5.11. Plant photosynthesis Part 2: The Kinetics of life processes 6. The rate of reactions 6.1. The definition of reaction rate 6.2. Rate laws and rate constants 6.3. Reaction order 6.4. The determination of the rate law 6.5. Intergrated rate law Temperature dependence of reaction rates 6.6. The Arrhenius equation 6.7. Preliminary interpreatation of the Arrhenius parameters 7. Accounting for the rate laws Reaction mechanisms 7.1. The approach to equilibrium 7.2. Elementary reactions 7.3. Consecutive reactions 7.4. Diffusion control 7.5. Kinetic and thermodynamic control 8. Complex biochemical processes Enzymes 8.1. The Michaelis-Menten mechanism of enzyme catalysis 8.2. The analysis of complex mechanisms 8.3. The catalytic efficiency of enzymes 8.4. Enzymes inhibition Transport across biological membranes 8.5. Molecular motion in liquids 8.6. Molecular motion across membranes 8.7. The mobility of ions 8.8. Transport across ion channels and ion pumps Electron transfer in biological systems 8.9. The rate of electron transfer processes 8.10. The theory of electron transfer processes 8.11. The Marcus cross-relation
Criteria for evaluation
Methods	writing of lecture details on the board Handouts powerpoint presentations interactive lecture
Language	English
Study material	1.Physical Chemistry for the Life Sciences, second edition, Peter Atkins and Julio de Paula, Oxford University Press. 2. Physical Chemistry, Principles and Applications in Biological Sciences, Fourth Edition, Ignacio Tinoco, Kenneth Sauer, James C. Wang, Joseph D. Puglisi, Pearson Educational International
Changing subject?	No
Corresponding lecture	in collaboration with 290PHCHCTDK18: KV Chemical Thermodynamics (1,5 ECTS) equivalent to BCBPPVOPHYC: VO Physical Chemistry 1 (5,2 ECTS)

On-site course
Maximum number of participants	-
Assignment procedure	Direct assignment