Inhalt
[ 663PHCHPC1V20 ] VL (*)Physical Chemistry for Biological Chemistry I
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| (*) Leider ist diese Information in Deutsch nicht verfügbar. |
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| Workload |
Ausbildungslevel |
Studienfachbereich |
VerantwortlicheR |
Semesterstunden |
Anbietende Uni |
| 4,5 ECTS |
B3 - Bachelor 3. Jahr |
Biologische Chemie |
Sabine Hild |
3 SSt |
Johannes Kepler Universität Linz |
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| Detailinformationen |
| Quellcurriculum |
Bachelorstudium Biological Chemistry 2018W |
| Ziele |
(*)The lecture conveys to the students the principles of physical chemistry and their application to the study of life sciences, particularly biology and biochemistry.
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| Lehrinhalte |
(*)Introduction
A. The structure of Physical Chemistry
B. Application of Physical Chemistry to Biology
Fundamentals
F1. Atoms, ions, and Molecules
F2. Bulk Matter
F3. Energy
Part 1: Biological Thermodynamics
1. The First Law
The Conservation of Energy
1.1. Systems and Surroundings
1.2. Work and Heat
1.3. The measurement of work
1.4. The measurement of heat
Internal energy and enthalpy
1.5. The Internal Energy
1.6. The Enthalpy
1.7. Enthalpy changes accompanying physical processes
1.8. Bond Enthalpy
1.9. Thermochemical properties of fuels
1.10. The combination of reaction enthalpies
1.11. Standard Enthalpy of formation
1.12. The Enthalpy of formation and computational chemistry
1.13. The variation of reaction enthalpy with temperature
2. The Second Law
Entropy
2.1. The direction of spontaneous changes
2.2. Entropy and the Second Law
2.3. Absolute entropies and the Third Law of Thermodynamics
2.4. The molecular interpretation of the Second Law and Third Laws
2.5. Entropy Changes accompanying chemical reactions
The Gibbs energy
2.6. Focusing on the System
2.7. The Hydrophobic interaction
2.8. Work and the Gibbs energy change
3. Phase (Physical) equilibra
The thermodynamics of transition
3.1. The condition of stability
3.2. The variation of Gibbs energy with pressure
3.3. The variation of Gibbs energy with temperature
3.4. Phase diagrams
Phase transitions in biopolymers and aggregates
3.5. The stability of nucleic acids and proteins
3.6. Phase transitions in biological membranes
The thermodynamic description of mixtures
3.7. The chemical potential
3.8. Ideal and ideal-dilute solutions
Colligative properties
3.9. The modification of boiling and freezing points
3.10. Osmosis
4. Chemical equilibria
Thermodynamic background
4.1. The reaction Gibbs Energy
4.2. The variation G with composition
4.3. Reactions at equilibrium
4.4. The standard reaction Gibbs energy
4.5. The presence of a catalyst
4.6. The effect of temperature
Proton transfer equilibria
4.7. Bronsted-Lowry theory
4.8. Protonation and deprotonation
4.9. Polyprotic acids
4.10. Amphiprotic systems
4.11. Buffer solutions
5. Thermodynamics of ions and electron transport
Transport of ions across biological membranes
5.1. Ions in solution
5.2. Passive and active transport of ions across biological membranes
5.3. Ion channels and ion pumps
Redox reactions
5.4. Half-reactions
5.5. Reactions in electrochemical cells
5.6. The Nernst equation
5.7. The standard potential
Applications of standard potentials
5.8. The determinationof thermodynamic functions
5.9. The electrochemical series
Electron transfer in bioenergetics
5.10. The respiratory chain
5.11. Plant photosynthesis
Part 2: The Kinetics of life processes
6. The rate of reactions
6.1. The definition of reaction rate
6.2. Rate laws and rate constants
6.3. Reaction order
6.4. The determination of the rate law
6.5. Intergrated rate law
Temperature dependence of reaction rates
6.6. The Arrhenius equation
6.7. Preliminary interpreatation of the Arrhenius parameters
7. Accounting for the rate laws
Reaction mechanisms
7.1. The approach to equilibrium
7.2. Elementary reactions
7.3. Consecutive reactions
7.4. Diffusion control
7.5. Kinetic and thermodynamic control
8. Complex biochemical processes
Enzymes
8.1. The Michaelis-Menten mechanism of enzyme catalysis
8.2. The analysis of complex mechanisms
8.3. The catalytic efficiency of enzymes
8.4. Enzymes inhibition
Transport across biological membranes
8.5. Molecular motion in liquids
8.6. Molecular motion across membranes
8.7. The mobility of ions
8.8. Transport across ion channels and ion pumps
Electron transfer in biological systems
8.9. The rate of electron transfer processes
8.10. The theory of electron transfer processes
8.11. The Marcus cross-relation
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| Beurteilungskriterien |
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| Lehrmethoden |
(*)- writing of lecture details on the board
- Handouts
- powerpoint presentations
- interactive lecture
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| Abhaltungssprache |
Englisch |
| Literatur |
(*)1.Physical Chemistry for the Life Sciences, second edition, Peter Atkins and Julio de Paula, Oxford University Press.
2. Physical Chemistry, Principles and Applications in Biological Sciences, Fourth Edition, Ignacio Tinoco, Kenneth Sauer, James C. Wang, Joseph D. Puglisi, Pearson Educational International
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| Lehrinhalte wechselnd? |
Nein |
| Äquivalenzen |
(*)in collaboration with 290PHCHCTDK18: KV Chemical Thermodynamics (1,5 ECTS) equivalent to
BCBPPVOPHYC: VO Physical Chemistry 1 (5,2 ECTS)
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| Präsenzlehrveranstaltung |
| Teilungsziffer |
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| Zuteilungsverfahren |
Direktzuteilung |
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