Inhalt

[ 663PHCHPC1V20 ] VL Physical Chemistry for Biological Chemistry I

Versionsauswahl
Workload Education level Study areas Responsible person Hours per week Coordinating university
4,5 ECTS B3 - Bachelor's programme 3. year Chemistry Sabine Hild 3 hpw Johannes Kepler University Linz
Detailed information
Original study plan Bachelor's programme Biological Chemistry 2018W
Objectives The lecture conveys to the students the principles of physical chemistry and their application to the study of life sciences, particularly biology and biochemistry.
Subject Introduction
A. The structure of Physical Chemistry
B. Application of Physical Chemistry to Biology

Fundamentals
F1. Atoms, ions, and Molecules
F2. Bulk Matter
F3. Energy

Part 1: Biological Thermodynamics
1. The First Law

The Conservation of Energy
1.1. Systems and Surroundings
1.2. Work and Heat
1.3. The measurement of work
1.4. The measurement of heat

Internal energy and enthalpy
1.5. The Internal Energy
1.6. The Enthalpy
1.7. Enthalpy changes accompanying physical processes
1.8. Bond Enthalpy
1.9. Thermochemical properties of fuels
1.10. The combination of reaction enthalpies
1.11. Standard Enthalpy of formation
1.12. The Enthalpy of formation and computational chemistry
1.13. The variation of reaction enthalpy with temperature

2. The Second Law
Entropy
2.1. The direction of spontaneous changes
2.2. Entropy and the Second Law
2.3. Absolute entropies and the Third Law of Thermodynamics
2.4. The molecular interpretation of the Second Law and Third Laws
2.5. Entropy Changes accompanying chemical reactions

The Gibbs energy
2.6. Focusing on the System
2.7. The Hydrophobic interaction
2.8. Work and the Gibbs energy change

3. Phase (Physical) equilibra

The thermodynamics of transition
3.1. The condition of stability
3.2. The variation of Gibbs energy with pressure
3.3. The variation of Gibbs energy with temperature
3.4. Phase diagrams

Phase transitions in biopolymers and aggregates
3.5. The stability of nucleic acids and proteins
3.6. Phase transitions in biological membranes

The thermodynamic description of mixtures
3.7. The chemical potential
3.8. Ideal and ideal-dilute solutions

Colligative properties
3.9. The modification of boiling and freezing points
3.10. Osmosis

4. Chemical equilibria

Thermodynamic background
4.1. The reaction Gibbs Energy
4.2. The variation G with composition
4.3. Reactions at equilibrium
4.4. The standard reaction Gibbs energy
4.5. The presence of a catalyst
4.6. The effect of temperature

Proton transfer equilibria
4.7. Bronsted-Lowry theory
4.8. Protonation and deprotonation
4.9. Polyprotic acids
4.10. Amphiprotic systems
4.11. Buffer solutions

5. Thermodynamics of ions and electron transport

Transport of ions across biological membranes
5.1. Ions in solution
5.2. Passive and active transport of ions across biological membranes
5.3. Ion channels and ion pumps

Redox reactions
5.4. Half-reactions
5.5. Reactions in electrochemical cells
5.6. The Nernst equation
5.7. The standard potential

Applications of standard potentials
5.8. The determinationof thermodynamic functions
5.9. The electrochemical series

Electron transfer in bioenergetics
5.10. The respiratory chain
5.11. Plant photosynthesis

Part 2: The Kinetics of life processes

6. The rate of reactions
6.1. The definition of reaction rate
6.2. Rate laws and rate constants
6.3. Reaction order
6.4. The determination of the rate law
6.5. Intergrated rate law

Temperature dependence of reaction rates
6.6. The Arrhenius equation
6.7. Preliminary interpreatation of the Arrhenius parameters

7. Accounting for the rate laws

Reaction mechanisms
7.1. The approach to equilibrium
7.2. Elementary reactions
7.3. Consecutive reactions
7.4. Diffusion control
7.5. Kinetic and thermodynamic control

8. Complex biochemical processes

Enzymes
8.1. The Michaelis-Menten mechanism of enzyme catalysis
8.2. The analysis of complex mechanisms
8.3. The catalytic efficiency of enzymes
8.4. Enzymes inhibition

Transport across biological membranes
8.5. Molecular motion in liquids
8.6. Molecular motion across membranes
8.7. The mobility of ions
8.8. Transport across ion channels and ion pumps

Electron transfer in biological systems
8.9. The rate of electron transfer processes
8.10. The theory of electron transfer processes
8.11. The Marcus cross-relation

Criteria for evaluation
Methods
  • writing of lecture details on the board
  • Handouts
  • powerpoint presentations
  • interactive lecture
Language English
Study material 1.Physical Chemistry for the Life Sciences, second edition, Peter Atkins and Julio de Paula, Oxford University Press.
2. Physical Chemistry, Principles and Applications in Biological Sciences, Fourth Edition, Ignacio Tinoco, Kenneth Sauer, James C. Wang, Joseph D. Puglisi, Pearson Educational International
Changing subject? No
Corresponding lecture in collaboration with 290PHCHCTDK18: KV Chemical Thermodynamics (1,5 ECTS) equivalent to
BCBPPVOPHYC: VO Physical Chemistry 1 (5,2 ECTS)
On-site course
Maximum number of participants -
Assignment procedure Direct assignment