[ 675GTSBSTBK13 ] KV Structural Bioinformatics

Workload Education level Study areas Responsible person Hours per week Coordinating university
3 ECTS B2 - Bachelor's programme 2. year (*)Bioinformatik Sepp Hochreiter 2 hpw Johannes Kepler University Linz
Detailed information
Original study plan Bachelor's programme Bioinformatics 2015W
Objectives Bioinformatics is an interdisciplinary field at the interface of life sciences and computational sciences that deals with the development and application of methods for storing, retrieving, and, in particular, analyzing biological data. The massive data amounts produced by recent and currently emerging high-throughput biotechnologies provide unprecedented potentials, but also pose yet unseen computational challenges – making bioinformatics an essential success factor for the advancement of fields, such as, molecular biology, genetics, medicine, and pharmacology.

The goal of this course is to provide an overview of foundational and computational aspects of 3D structures of biological macromolecules, such as, DNA, RNA, and proteins. The main goal of structural bioinformatics is to provide computational approaches for predicting and analyzing 3D structures. Understanding the 3D structures of biological macromolecules is crucial for understanding their function. Applications of structural bioinformatics are oriented towards medical fields and pharmacological research, especially, drug design.

  • Databases for 3D structures and molecular viewers
  • Structure prediction (threading, ab initio prediction, molecular dynamics)
  • Structural alignments
  • Protein classification
  • Motif search
  • Functional and structural annotation
Criteria for evaluation The final grade is based on a combined assessment of homework and a final exam.
Methods Slide presentations
Language English
Study material Electronic course material is made available for download
Changing subject? No
On-site course
Maximum number of participants 35
Assignment procedure Direct assignment