| Detailinformationen |
| Quellcurriculum |
Bachelorstudium Bioinformatics 2013W |
| Ziele |
(*)1. To provide an introduction to genetics and evolution to aid in the interpretation of genomic data
2. Focus on relevant definitions and topics in genetics and evolution
3. Introduce students to main concepts in evolution
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| Lehrinhalte |
(*)1. The flow of information
- Biological dogma: From genes to proteins
- The genetic code
2. Basic concepts in Population genetics
- Genotype and phenotype
- Polymorphisms and heterozygosity
- Allele frequency
- Hardy-Weinberg equilibrium
- Frequency of homozygous and heterozygotes
- Nucleotide diversity and divergence
3. Processes that change our genome
A. Mutations
- Types of mutations
- How are mutations introduced
- Repair pathways
- Paternal age effect
B. Meiotic recombination
- Process of meiosis
- Types of recombination
- How does recombination introduce new variations?
- What is genetic distance?
- Pedigree maps
- Linkage disequilibrium
- Recombination hotspots
D. Random neutral evolutionary processes
- Random Genetic drift
- Bottlenecks
D. Selection
- Selection on variation
- Balancing selection
- Mutation and selection
4. The evolution of our genome
- Evolutionary biology is a valuable tool
- Placing humans on the tree of life
- Genetics and human evolution
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| Beurteilungskriterien |
(*)• Exercises: Results from homework—Report due after a predefined date.
• Final exam: short answer / multiple choice questions / exercises
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| Lehrmethoden |
(*)Lectures will be combined with exercises explained in class. Exercises to solve outside of class will strengthen the taught concepts.
|
| Abhaltungssprache |
Englisch |
| Literatur |
(*)1. Principles of Population Genetics by Daniel Hartl and Andrew Clark ed. (Sinauer, 2nd edition 2009).
2. Evolution (CSHL by Nicholas Barton, Derek Briggs, Jonathan Eisen, David Goldstein, Nipam Patel, ed. )
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| Lehrinhalte wechselnd? |
Nein |
