| Students develop the ability to understand the principles underlying the work of io-selective carriers and channels. They learn to interpret structural data related to membrane transport proteins, including the requirements for facilitated ion transport. Additionally, they gain an understanding of how key experimental techniques such as electrophysiology, optical spectroscopy, fluorimetry, light microscopy, crystallography and cryo-EM may be applied to investigate transport proteins, enabling them to critically assess research in the field.
|
Principles of membrane ion selective transport, function of model channels (antibiotics), structure-function relation of selective potassium channels, sodium channels, cyclic nucleotide gated channels, aquaporins, chloride channels and transporters, solute carriers, and pentameric ligand gated ion channels. Mechanism of channel inactivation, voltage sensing, and ligand induced activation.
|
