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| Detailed information |
| Original study plan |
Bachelor's programme Chemistry and Chemical Technology 2025W |
| Learning Outcomes |
Competences |
| Students will be able to understand and appreciate the molecular basis of cellular chemistry. They will know the key reactions and reactants of central processes in biochemistry (glycolysis, gluconeogenesis, TCA cycle, oxidative phosphorylation) and about the importance of biomolecules in mediating and regulating these vital metabolic processes. They can illustrate this learning with examples.
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| Skills |
Knowledge |
| Students can recognize and name the natural amino acids (in single and three letter code) (k1), recognize the five ribonucleotides (k1), describe the polymerization reactions that form proteins, RNA, DNA, polysaccharides, and name the elements that build these chemical structures (k1,k2). Students can explain the non-covalent interactions that stabilize biological structures (k2,k3). Students can describe the sequences of chemical reactions of glycolysis and the Krebs (TCA) cycle (k1). Students can explain the concepts of biological feedback loops and regulation of key metabolic reactions (k2,k3). Students can describe the sequences of chemical reactions of gluconeogenesis and name the primary metabolites that are converted to glucose (k1). They can describe the key difference between glycolysis and gluconeogenesis (k4). Students can explain how glucose is converted in anaerobic and aerobic mechanisms, and how ATP is synthesized by oxidative phosphorylation (k1,k2). They can explain what the proton motive force is and understand concepts like energy charge of the cell (k1,k2). Students can explain how the structures of myoglobin, hemoglobin and fetal hemoglobin support their biological function (k1,k2). They can explain the Bohr effect and the cooperativity of oxygen binding and release (k1,k2,k3).
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• Molecular structure and biochemical concepts
• Protein composition and structure at several levels
• How enzymes work
• How the structure of hemoglobin supports its oxygen-binding function
• The reactions of central metabolism; glycolysis and gluconeogenesis
• The reactions that form the TCA cycle and its regulation.
• Oxidative phosporylation, buildup of the PMF, and the synthesis of ATP
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| Criteria for evaluation |
final exam
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| Methods |
lecture
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| Language |
English |
| Study material |
Biochemistry: A Short Course by John L. Tymoczko, Jeremy M. Berg, Gregory J. Gatto Jr., Lubert Stryer
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Biochemistry by Gregory Gatto Jeremy M. Berg, Lubert Stryer, John Tymoczko
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| Changing subject? |
No |
| Corresponding lecture |
TCBPFVOBICH: VO Biochemistry (2,6 ECTS)
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