Inhalt
[ 863CTBCBCAV19 ] VL Biocatalysis
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| Workload |
Education level |
Study areas |
Responsible person |
Hours per week |
Coordinating university |
| 1,5 ECTS |
M1 - Master's programme 1. year |
(*)Biologische Chemie |
Marko Hapke |
1 hpw |
Johannes Kepler University Linz |
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| Detailed information |
| Original study plan |
Master's programme Biological Chemistry 2025W |
| Learning Outcomes |
Competences |
| The lecture will include on the following core areas:
a) Repetition of basics of enzyme kinetics and protein chemistry: students will revisit fundamental concepts in enzyme kinetics and protein chemistry, reinforcing their foundational knowledge in these areas; b) Understanding of structure and function of enzymes: students will gain a comprehensive understanding of the structural features of the different classes of enzymes and how these structures relate to their catalytic functions; c) Discussion of enzyme catalysis mechanisms: the lecture will cover the different enzyme classes and various reaction mechanisms of enzyme catalysis, providing students with insights into how enzymes accelerate (bio)chemical reactions; d) Understanding of uses and areas of application of enzymes: the diverse applications of enzymes in various fields of biocatalysis will be presented, including particularly biotechnology and industry processes.
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| Skills |
Knowledge |
| The contents of the course will enable them to
• repeat, understand and master the basics of enzyme kinetics and protein chemistry (k1, k2, k3)
• understand, analyze and assess the structures of enzymes and their role in the function of enzymes (k2, k4, k5)
• understand and distinguish the different classes of enzymes (k2, k4)
• understand and distinguish different reaction mechanisms and active centres for the enzyme classes (k2, k4)
• understand, implement and assess enzyme catalysis in biocatalysis, including small molecule synthesis and industrial biocatalysis (k2, k4, k5)
• understand and analyze the development of artificial enzymes (e.g. synzymes, abzymes, etc.) and modification of enzymes e.g. by directed evolution (k2, k4)
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• enzyme kinetics and protein chemistry
• composition and structure of enzymes
• discussion of enzyme classes and individual examples
• discussion of reaction mechanisms of enzymes
• (industrial) application and uses of enzymes
• artificial enzymes and directed evolution
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| Criteria for evaluation |
Written exam at the end of the semester
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| Methods |
Power point presentation; additional explanations at the blackboard; discussion of questions
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| Language |
English |
| Study material |
- Catalysis, G. Rothenberg, Wiley-VCH, 2017, 2nd edition (1st edition free accessible online via library)
- Introduction to Enzyme and Coenzyme Chemistry, T. D. H. Bugg, Wiley
- Enzyme, H. Bisswanger, Wiley-VCH
Further specialised general literature and references are given in the first lecture and when appropriate.
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| Changing subject? |
No |
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| On-site course |
| Maximum number of participants |
- |
| Assignment procedure |
Direct assignment |
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