The course is focused on the field of pharmaceuticals which are produced by biotechnology approaches with the use of genetically modified both prokaryotic and eukaryotic organisms. In the opening parts, students will gain the basic information on the way of production of these biological drugs together with a basic information on related regulatory affairs. The course will then analyze differences between biological drugs and classical synthetic ones. After this introduction the main groups of indications and individual drugs will be presented. The aim of this part is good understanding of mechanism of action of these drugs and possible risk factors. To give students basic information on this field of biological pharmaceuticals which represent currently most dynamic developing filed of pharmaceuticals. To give overview of current drugs, their structure, production and biological effects. Basic principles of human patho-physiology will explained to reflect the mechanism of action of these drugs. In the last part of lectures students will prepare their own presentation on given themes so they will be actively participating in the lectures and discussions. The program of the course is based upon similar program already running at the VSCHT by the same lecturer.